Research
We build experimental platforms that connect RNA-binding events, spatial organization, and therapeutic design.
A central pillar of our research is the development of advanced nucleic acid detection methodologies. We focus on engineering high-sensitivity, high-resolution platforms to profile RNA-protein interactions, particularly within limited or challenging biological samples.
Inspired by ARTR-seq and protein-centered RNA-protein interaction studies.
To bridge the gap between molecular mechanisms and tissue architecture, we develop spatially resolved RNA sequencing technologies. These tools allow us to visualize the spatial organization of RNA regulation in situ, revealing how the cellular microenvironment shapes transcriptional and post-transcriptional coordination.
Concept aligned with spatial m6A profiling using m6A-ARTR-DBiT.
Ultimately, we aim to translate these mechanistic insights into therapeutic innovation. By leveraging our understanding of RNA-binding proteins and regulatory circuits, we are designing next-generation RNA-based therapeutics with enhanced clinical specificity.
Extending mechanistic RNA regulation toward programmable intervention.