Nucleic acid detection
Engineering sensitive methods for profiling RNA-protein interactions and regulatory features in limited biological samples.
Department of Chemistry / Fudan University
Xiao Lab
We develop chemical biology tools to map RNA regulation with high sensitivity, spatial resolution, and translational intent.
RNA regulation in context
From molecular mechanisms to spatially resolved biology.
A central pillar of our research is the development of advanced nucleic acid detection methodologies. We focus on engineering high-sensitivity, high-resolution platforms to profile RNA-protein interactions, particularly within limited or challenging biological samples.
We pair technology development with biological discovery, aiming to uncover how RNA regulatory circuits shape cell state, tissue architecture, and disease-relevant processes.
Research directions
Core interests
Spatial RNA sequencing
Developing in situ approaches that connect RNA regulation to tissue organization and microenvironmental context.
RNA-based therapeutics
Translating mechanistic insights into next-generation RNA therapeutics with improved biological specificity.
Recent work